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Check Carefully (1)modafinil will increase levels of eluxadoline by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. To be a precautionary evaluate as a consequence of incomplete information on the metabolism of eluxadoline, use warning when coadministered with potent CYP2C19 inhibitors.Doses up to 400 mg/day, specified as just one d